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CAS No. 208538-73-2 | Micafungin sodium

Name: Micafungin sodium CAS No. 208538-73-2 MF:C56H72N9NaO23S MW:1294.28 Purity:97% Package: 1g,5g,10g,25g,50g Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 208538-73-2 | Micafungin sodium

Synonyms:1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandinA0MonosodiuMSalt;

Funguard;

MicafunginSodiuM(FK-463,MycaMine);

Mycamine;

MicafunginSodiumSalt;

FK463Sodium;

MicafunginsodiumMycamine

Specification:

ITEMS	SPECIFICATION
CAS	208538-73-2
MF	C56H72N9NaO23S
MW	1294.28
Melting point	>180°C
Color	White to off-white
Solubility	Soluble in DMSO (slightly), methanol (slightly), water (slightly, sonication)
Form	Solid
Storage condition	Keep in dark place,Sealed in dry,Store in freezer, under -20°C

preparation:

Dissolve 1.0kg of micafungin DIPEA salt (purity 98.80%) in 10L purified water, filter to remove insoluble substances in the solution; dissolve 6.6kg of disodium hydrogen phosphate and 2.8kg of sodium dihydrogenphosphate in 200L of purified water, and use phosphoric acid Adjust the pH value to 5.8 to prepare a sodium salt solution.

(2) Add 30L of the sodium salt solution in the previous step to the aqueous solution of micafungin DIPEA salt, stir and mix, and cool to 10°C. Filter through a constant volume filtration equipment, and add sodium salt solution and sodium salt solution during the filtration process. The addition rate is equal to the membrane flux of the membrane module; control the system temperature to 10°C and the operating pressure to 0.5-1.5MPa until the detection amount of DIPEA in the filtrate reaches zero.

(3) Replace the sodium salt solution with purified water, and keep the addition rate of purified water equal to the membrane flux of the membrane module until the conductivity of the filtrate and purified water are basically equal.

(4) Lyophilize the pure micafungin sodium aqueous solution obtained in the previous step to obtain 920g of micafungin sodium solid, with a yield of 99%, a purity of 99.24%, and an ignition residue of 5.5%.

Clinical application:

Micafungin sodium is highly active not only against Candida and Aspergillus, but also against azole- and amphotericin B-resistant strains. Candidiasis and aspergillosis can be treated alone and in combination with other antifungals in immunocompromised patients and have also been found to be effective in preventing fungal infections in patients undergoing stem cell transplantation.

Package and transportation :

Package: 1g,5g,10g,25g,50g